Pharmingen

San Diego, CA 92121

SBIR Award Summary

Total Number of Awards 9
Total Value of Awards $0.0
First Award Date 09/30/88
Most Recent Award Date 07/01/95

Key Personnel

Last Name Name Awards Contact
Huang Chunming Huang 6
Shih Charles C-Y Shih 1
Gruenwald Stefan Gruenwald 1
Singh Sujay K Singh 1

9 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/95 - 12/31/95

Serotonin (5-hydroxytryptamine; 5-HT) mediates many central and nervous system functions by its interaction with specific neuronal receptors. It is well established that 5-HT receptors are related to anxiety and mental depression. 5-HT receptors are also binding sites for hallucinogenic drugs. Physiological fu...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/09/95 - 06/30/95

The t(l; 19) translocation in pediatric ALL identifies a subgroup of patients with poor prognosis who might benefit from more aggressive chemotherapy. This reciprocal translocation results in the expression of a novel fusion protein with oncogenic properties which is not expressed in normal tissues. Antibodies to this fusion protein can serv...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/10/93 - 01/09/94

DESCRIPTION: (Adapted from the applicant's abstract) RMS has been recognized as one of the most common malignant soft tissue tumors afflicting children, adolescents, and young adults. Because these tumors are small-, round-cells, it is very difficult to differentiate them from tumors such as Ewing's sarcoma, neuroblastoma, nephroblastoma and m...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/93 - 09/30/93

Each year more than one hundred thousand cases of prostate cancer have been diagnosed in the United States and which is the first in solid tumor incidence and second in cancer related death in the American male population. Yet, the factors which are involved in prostate carcinogenesis, except for the presence of androgen, remain unclear. Recent...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/06/92 - 07/31/92

Evidences suggest that inactivation of specific "tumor suppressor" genes contributes to the formation of several human cancer types including retinoblastoma (Rb), osteosarcoma, Wilms' tumor, neurofibromatosis, small cell lung carcinoma, and adenocarcinomas of breast and colon. The tumor suppressor genes Rb,p53,WT1,NF-1,DCC and MCC have been clo...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/91 - 07/31/92

Retinoblastoma (RB) gene is the prototype cancer suppressor gene allowing tumor induction to occur in the absence of the normal RB gene product (RB protein). Recent studies with DNA and antibody probes have revealed that in addition to the prototype retinoblastoma, many other tumor cells show RB gene/protein defects. These include osteosarcoma...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/91 - 12/31/91

DESCRIPTION: (Adapted from the Applicant's Abstract) Recent evidence suggests that mutational inactivation of specific "tumor suppressor" genes contributed to the formation of several human cancer types including retinoblastoma (Rb), osteosarcoma, small cell lung carcinoma, and adenocarcinomas of breast and colon. The tumor suppressor genes, R...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/90 - 03/31/91

Retinoblastoma (RB) gene is the prototype cancer suppressor gene allowing tumor induction to occur in the absence of the normal RB gene product (RB protein). Recent studies with DNA and antibody probes have revealed that in addition to the prototype retinoblastoma, many other tumor cells show RB gene/protein defects. These include osteosarcoma...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/88 - 03/31/89