Biosym Technologies, Inc.

10065 Barnes Canyon Rd Ste A
San Diego, CA 92121

SBIR Award Summary

Total Number of Awards 13
Total Value of Awards $299K
First Award Date 03/01/85
Most Recent Award Date 03/01/93

Key Personnel

Last Name Name Awards Contact
Dinur Uri Dinur 1
Mackay Donald H Mackay 3
Haney David N Haney 1
Hempel Judith C Hempel 1
Thacher Thomas Stevens Thacher 3
Fine Richard Masten Fine 1
Meirovitch Eva Meirovitch 1
Lee Richard H Lee 2

13 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/93 - 02/28/95

DESCRIPTION (Adapted from Applicant's Abstract):This proposal is to implement the techniques of sensitivity analysis as a means to 1) quantatitvely assess the relationship between the potential and the observables calculated using molecular mechanics and dynamics; and 2)to quantitatively assess the relationship between the function of a biomolec...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/92 - 02/28/93

DESCRIPTION (Adapted from Applicant's Abstract):This proposal is to implement the techniques of sensitivity analysis as a means to 1) quantatitvely assess the relationship between the potential and the observables calculated using molecular mechanics and dynamics; and 2)to quantitatively assess the relationship between the function of a biomolec...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/91 - 06/30/92

DESCRIPTION: (Adapted from Applicant's Abstract) The objective of this proposal is to carry out the scientific testing associated with a new NMR software package developed currently at Biosym, namely an integrated theoretical/computational tool for determining molecular structures from NMR data. The scheme combines an elaborate NMR Relaxation ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/15/91 - 07/14/91

The biological activity of polypeptides and proteins is determined, to a large extent, by their spatial structure. Therefore, calculation of the free energy F is important since minimum F is the criterion for conformational stability. However, with the usual simulation techniques calculation of F is difficult. The "local states method" sugges...

Phase 2 SBIR

Agency: National Science Foundation
Topic: 1991
Budget: 01/01/91 - 12/31/91

BECAUSE OF INNOVATIONS IN THE BIOTECHNOLOGY INDUSTRY, PROTEIN SEQUENCE DATA IS BECOMING AVAILABLE AT AN EVER INCREASING RATE. SINCE STRUCTURAL INFORMATION OBTAINED FROMX-RAY CRYSTALLOGRAPHY OR NMR ANALYSIS IS OBTAINED MUCH MORE SLOWLY, THERE ARE MANY PROTEINS CRITICAL TO ONGOING RESEARCHFOR WHICH AMINO ACID SEQUENCES ARE KNOWN, BUT ATOMIC COORDI...

Phase 1 SBIR

Agency: National Science Foundation
Topic: 1990
Budget: 01/01/90 - 12/31/90

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/22/89 - 03/21/90

Our long term objective is to apply state-of-the-art computer simulation software techniques including molecular dynamics, molecular mechanics and interactive graphics analysis to the understanding of the conformational preferences of biologically active peptides in order to guide and stimulate the design of peptide and non-peptide analogs that ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/89 - 08/31/89

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/87 - 06/30/88

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/87 - 09/30/87

The overall objective of this work is to extend receptor based drug design to include the use of modern state-of-the-art simulation of the structure, energetics, and dynamics of protein-protein and protein-ligand interactions. In particular, we propose to use these techniques to model an alpha-hemoglobin tetramer and to use information obtained...

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