Genpharm International, Inc.

San Jose, CA 95131

SBIR Award Summary

Total Number of Awards 12
Total Value of Awards $0.0
First Award Date 04/01/91
Most Recent Award Date 08/01/94

Key Personnel

Last Name Name Awards Contact
Huszar Dennis Huszar 2
Choi Ted Choi 3
Loring Jeanne Frances Loring 2
Lonberg Nils Lonberg 3
Huang Manley T F Huang 1
Kay Robert M Kay 1

12 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/94 - 07/31/95
PI: Ted Choi

The goal of GenPharm's program is to develop methods for the introduction of yeast artificial chromosomes (YACs) into the germline of mice, and to apply the technology toward the generation of transgenic mice expressing a broad, fully human immunoglobulin repertoire. These mice would permit the isolation of human monoclonal antibodies in an anal...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/94 - 07/31/95

Monoclonal antibodies have been shown to represent an important class of therapeutic proteins with applications in various disease states. The goal of GenPharm's program is to inactivate the endogenous mouse immunoglobulin (Ig) repertoire to ensure the generation of purely human antibodies from human Ig transgenics, enabling the production of th...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/01/94 - 12/31/94

Mouse embryonic stem (ES) cells inaugurated a new era for mouse geneticists, by allowing them to mutate specific genes and also produce mice carrying large genomic transgenes. If it were possible to manipulate the rat genome in a similar manner through rat ES cells, the powerful database of rat physiology and behavior could be exploited to produ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/15/93 - 07/31/94
PI: Ted Choi

The goal of GenPharm's program is to develop methods for the introduction of yeast artificial chromosomes (YACs) into the germline of mice, and to apply the technology toward the generation of transgenic mice expressing a broad, fully human immunoglobulin repertoire. These mice would permit the isolation of human monoclonal antibodies in an anal...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/15/93 - 07/31/94

Monoclonal antibodies have been shown to represent an important class of therapeutic proteins with applications in various disease states. The goal of GenPharm's program is to inactivate the endogenous mouse immunoglobulin (Ig) repertoire to ensure the generation of purely human antibodies from human Ig transgenics, enabling the production of th...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/93 - 07/31/94

Monoclonal antibodies have been shown to represent, as a class of molecules, important therapeutic proteins with application in various disease states. The goal of GenPharm's program is to provide access to the human immunoglobulin repertoire such that human monoclonal antibodies can be isolated in an analogous manner to rodent monoclonal antib...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/92 - 07/31/93

Monoclonal antibodies have been shown to represent, as a class of molecules, important therapeutic proteins with application in various disease states. The goal of GenPharm's program is to provide access to the human immunoglobulin repertoire such that human monoclonal antibodies can be isolated in an analogous manner to rodent monoclonal antib...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/92 - 10/31/92
PI: Ted Choi

The goal of GenPharm's program is to develop methods for the introduction of yeast artificial chromosomes (YACs) into the germline of mice, and to apply the technology toward the generation of transgenic mice expressing a broad, fully human immunoglobulin repertoire. These mice would permit the isolation of human monoclonal antibodies in an ana...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/92 - 08/31/92

DESCRIPTION (Adapted from applicant's abstract):The rat is a major experimental animal for biomedical research in the fields of pharmacology, transplantation, cancer, toxicology, physiology, immunology, aging, neurobiology, and drug discovery and development. The goal of this proposal is to provide a technical means to introduce modifications in...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/15/92 - 08/14/92

DESCRIPTION: (Adapted from the applicant's abstract) Immunodeficient mouse strains have played an important role in the analysis of the immune system and the development of animal models for human disease. A broad spectrum of naturally occurring murine immunodeficiencies have been discovered, however, no defects which fully and selectively lim...

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