Genetics Institute, Inc.

87 Cambridge Park Drive
Cambridge, MA 02140

SBIR Award Summary

Total Number of Awards 10
Total Value of Awards $240K
First Award Date 01/01/84
Most Recent Award Date 09/01/89

Key Personnel

Last Name Name Awards Contact
Collins Mary Collins 1
Kamen Robert I Kamen 1
Kaufman Randal J. Kaufman 5
Shoemaker Charles Bix Shoemaker 1
Rozzell J. David Rozzell Jr. 2

10 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/89 - 08/31/90

Monoclonal antibodies have great potential as a unique set of highly specific reagents for the prophylaxis, diagnosis and therapy of human diseases. However, a major problem encountered is the immunogenicity of these murine antibodies which limits their usefulness. In addition, human antibodies may be more efficient than mouse antibodies in me...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/89 - 02/28/90

Factor VIII is the plasma protein which is functionally deficient in hemophilia A patients, resulting in the clinical bleeding disorder. Patients with this disease require frequent infusions of Factor VIII in order to maintain hemostasis, particularly during surgery or following physical trauma. Presently, the commercial Factor VIII product is...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/88 - 08/31/89

Monoclonal antibodies have great potential as a unique set of highly specific reagents for the prophylaxis, diagnosis and therapy of human diseases. However, a major problem encountered is the immunogenicity of these murine antibodies which limits their usefulness. In addition, human antibodies may be more efficient than mouse antibodies in me...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/31/88 - 02/28/89

Factor VIII is the plasma protein which is functionally deficient in hemophilia A patients, resulting in the clinical bleeding disorder. Patients with this disease require frequent infusions of Factor VIII in order to maintain hemostasis, particularly during surgery or following physical trauma. Presently, the commercial Factor VIII product is...

Phase 2 SBIR

Agency: National Science Foundation
Topic: 1987
Budget: 01/01/87 - 12/31/87

HYPOTHESES ABOUT THE STABILIZATION OF ENZYMES BY COVALENT ATTACHMENT TO SOLUBLE POLYMERS ARE TO BE TESTED IN DETAIL TO ISOLATE THE EFFECT OF MULTI-POINT ATTACHMENT FROM OTHER FACTORS KNOWN TO AFFECT ENZYME STABILITY INCLUDING CHEMICAL MODIFICATION, REDUCED PROTEOLYSIS, DIFFUSIONAL EFFECTS, AND SUBUNIT DISSOCIATION. TWO MODEL ENZYME SYSTEMS HAVE ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/86 - 12/31/86

Monoclonal antibodies have immense potential for use as prophylactic, diagnositc, and therapeutic agents in the treatment of various types of human ailments. For many uses it is desireable to use human monoclonal antibodies as opposed to murine monoclonal antibodies. Although many approaches have been attempted to produce human monoclonal ant...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/01/86 - 06/30/86

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/01/86 - 06/30/86

Current techniques for the diagnosis of genetic disease are limited by an inability to detect the majority of mutations and polymorphisms in DNA. DNA molecules which differ by one or a few base pairs can most efficiently be distinguished currently by denaturing gradient gel electrophoresis due to sequence specific differences in melting properti...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 12/01/85 - 05/31/86

Factor VIII is the plasma protein which is functionally deficient in hemophilia A patients, resulting in the clinical bleeding disorder. Patients with this disease require frequent infusions of factor VIII in order to maintain hemostasis, particularly during surgery or following physical trauma. Presently, the commercial factor VIII product is ...

Phase 1 SBIR

Agency: National Science Foundation
Topic: 1984
Budget: 01/01/84 - 12/31/84

Load More