Synaptic Pharmaceutical Corporation

Paramus, NJ 07652

SBIR Award Summary

Total Number of Awards 25
Total Value of Awards $0.0
First Award Date 07/01/89
Most Recent Award Date 07/01/97

Key Personnel

Last Name Name Awards Contact
Forray Carlos Forray 1
Gluchowski Charles Gluchowski 1
Hartig Paul R Hartig 7
Weinshank Richard L Weinshank 3
Branchek Theresa A Branchek 2
Finn John M Finn 1
Bard Jonathan A Bard 1
Wetzel John M Wetzel 3
Borden Lawrence A Borden 1
Salon John A Salon 4
Noble Stewart A Noble 1

25 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/97 - 12/31/97

The objective of this proposal is the discovery of antagonists for the neuropeptide Y (NPY) Y2 subtype of receptor to further define the role of this receptor in mediating the diverse pharmacological properties of NPY. The authors propose and present data in support of a computational approach ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/97 - 05/31/98

Alpha 1 and alpha 2 adrenergic receptors serve numerous functions throughout the central and peripheral nervous systems and, as such, have served as useful targets for the development of drugs to treat of a number of disorders such as narcolepsy, intractable pain, hypertension, benign prostatic hyperplasia a...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/96 - 06/30/97

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/96 - 05/31/97

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/96 - 04/30/97

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/95 - 08/31/96

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/15/94 - 03/14/95

Alpha adrenoceptors serve numerous functions throughout the peripheral and central nervous systems. Chemical modulators of these receptors have a variety of potential therapeutic applications, including treatments for benign prostatic hyperplasia, hypertension, pain and glaucoma. Although six alpha adrenoceptor subtypes are now known, little in...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/94 - 08/31/95

Neuropeptide Y (NPY) has been implicated in a variety of pathological conditions including; cardiovascular and respiratory abnormalities, mental depression, Parkinson's and Alzheimer's disease. A structure-based drug design program to develop NPY peptidomimetics for intervention in these disorders would be facilitated by a structural model of th...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/94 - 10/31/94

Activation of a subset of serotonin receptors evokes physiological responses characteristic of adenylate cyclase stimulation in a wide variety of tissues: neuronal depolarization, relaxation of smooth muscle, and positive inotropy in cardiac muscle. The receptor subtypes will serve as drug targets for potential therapeutic roles in irritable b...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/01/94 - 06/30/94

The use of oligonucleotide probes to modulate the synthesis of protein molecules has had important implications in understanding the growth of viruses and expression of oncogenes. More recently, antisense strategies have been employed in studies examining the nervous system. The applications of this methodology are numerous. Essentially, this ...

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