Medarex, Inc.

Princeton, NJ 08540

SBIR Award Summary

Total Number of Awards 16
Total Value of Awards $853K
First Award Date 09/30/88
Most Recent Award Date 09/15/05

Key Personnel

Last Name Name Awards Contact
Bodwell Jack E Bodwell 2
Dinces Nathan Dinces 1
Ely Pamela Ely 3
Graziano Robert F Graziano 5
Gosselin Edmund J Gosselin 1
Keler Tibor P Keler 3
Shlomchik Warren D Shlomchik 1

16 Awards Won

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 09/15/05 - 09/14/06

DESCRIPTION (provided by applicant): Allogeneic stem cell transplantation (alloSCT) can be life-saving therapy for malignant and nonmalignant diseases. T cells that accompany allogeneic stem cell grafts are vital for immune reconstitution, particularly in adults with little thymic function. Unfortunately, donor T cells also cause Graft-vs.-Host...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PAS-02-149
Budget: 05/15/05 - 04/30/06

DESCRIPTION (provided by applicant): The long term goal of this proposal is to develop a novel targeted vaccine technology against emerging infectious diseases and pathogens associated with bioterrorism. Previous studies have documented the extremely rapid and potent immune responses elicited by vaccines that target antigens specifically to pro...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/00 - 02/28/01

Gastrin-Releasing Protein (GRP) is the mammalian analog of bombesin, a 14- amino acid peptide initially isolated from the skin of the frog Bombina bombina. GRP receptors are expressed on a variety of human tumors including small cell carcinoma of the lung (SCCL), and breast cancer, but are rarely present on normal cells. Previous studies have ...

Phase 2 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/00 - 04/30/02

Using current chemotherapies, the majority of patients with B cell non- Hodgkin's lymphoma (NHL) will die of their disease. Immunologic approaches to NHL offer the possibility of enhancing chemotherapeutic responses. Anti-idiotypic antibodies, unlabeled monoclonal antibodies and antibodies conjugated t...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/13/99 - 08/31/02

DESCRIPTION: (Adapted from the applicant's abstract) The high affinity Fc receptor for human IgG [Fc-gRI or CD64] is an important cytotoxic trigger molecule on monocytes, macrophages and activated neutrophils. One of the investigators' Fc-gRI-specific MAb, M22, has been humanized by CDR grafting and renamed H2...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/99 - 02/29/00

The long term goal of the application is to develop a treatment for antibiotic-resistant Staphylococcus aureus infections using human monoclonal antibodies. Methicillan-resistant S. aureus (MRSA) are a major cause of nosocomial infections worldwide, and effective treatment of these infections is currently managed with a relatively toxic antibio...

Phase 2 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 05/04/99 - 04/30/00

Using current chemotherapies, the majority of patients with B cell non- Hodgkin's lymphoma (NHL) will die of their disease. Immunologic approaches to NHL offer the possibility of enhancing chemotherapeutic responses. Anti-idiotypic antibodies, unlabeled monoclonal antibodies and antibodies conjugated t...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/98 - 08/31/99

DESCRIPTION: (Adapted from the applicant's abstract) The high affinity Fc receptor for human IgG [Fc-gRI or CD64] is an important cytotoxic trigger molecule on monocytes, macrophages and activated neutrophils. One of the investigators' Fc-gRI-specific MAb, M22, has been humanized by CDR grafting and renamed H2...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/98 - 06/30/00

DESCRIPTION: (Adapted from the investigator's abstract) Targeting immunogens to antigen presenting cells (APC) significantly enhances T cell activation and antibody production in vitro and in vivo, respectively, eliminating the need for traditional adjuvants. This proposal focuses on developing a biotin-bin...

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/96 - 03/31/98

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