Hipple Cancer Research Corporation

Dayton, OH 45439

SBIR Award Summary

Total Number of Awards 25
Total Value of Awards $0.0
First Award Date 09/01/88
Most Recent Award Date 01/01/96

Key Personnel

Last Name Name Awards Contact
Fuhrer John P Fuhrer 3
Murphy Martin J Murphy 17
Gupta Sohan L Gupta 2
Wang Yisheng Wang 1
Natarajan Kunthavi Natarajan 1
Barbera Emilio Barbera 1

25 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/01/96 - 07/31/97

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/95 - 01/31/96

DESCRIPTION: The objective of this feasibility study is development of a sensitive instrument, based on image analysis, able to count megakaryocyte colonies (CFU-meg), the number of megakaryocytes per colony, megakaryocyte maturation and cell ploidy. This automatic counter can be used to:...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/95 - 11/30/95

Patients infected with human-deficiency virus (HIV)-1 resulting in the development of acquired immune deficiency syndrome (AIDS) often develop neurological disease named AIMS Dementia Complex (ADC). The underlying basis of ADC is not clearly understood. Models proposed include a direct toxicity of HIV protein...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/95 - 04/30/96

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/20/95 - 10/19/95

Cervical cancer represents the second most frequent cancer in women after breast cancer. Human papillomaviruses (HPVs) are implicated as a causative agent in several human cancers, especially squamous tumors of the cervix and anogenital region, the risk being highest with HPV types 16 and 18. The ca...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/20/95 - 10/19/95

Description: This Phase I application is concerned with the secretion of (G-CSF by bone marrow mononuclear cells and its stimulation by a combination of retinoids and natural product extract from a Chinese fungus ("fungal extract": FE). Retinoids are used clinically to prevent and treat certain types...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/95 - 02/29/96

Amine oxidases in bovine serum generate products that are cytotoxic and mutagenic to cultured human and murine cells. Short-term toxicity of these byproducts is seen as a lack of survival of hematopoietic progenitor cells, associated with low cloning efficiencies. Long-term toxicity is seen as in ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/01/95 - 12/31/95

DESCRIPTION: Since thrombocytopenia is a serious life threatening complication of cancer and AIDS chemotherapy, standardized and optimized human assays for human megakaryocyte progenitors would be useful for determining and/or predicting the toxicity of experimental chemotherapeutic drugs. The proposed experiments in this Phase I...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/94 - 09/29/95

The production of megakaryocytes from progenitor cells in the marrow can be stimulated by a lineage-specific factor - megakaryocyte colony-stimulating factor (Meg-CSF). The lineage-specific stimulation of megakaryocytes by Meg-CSF and subsequent increase in platelet number has great clinical significance in treating thrombocytopenia resulting f...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/94 - 09/29/95

DESCRIPTION (Obtained from the applicant's abstract): The Hipple Cancer Research Corporation developed patented technology (CapScanTM) for quantitating particles inside microcapillary tubes, includingtumor cell colonies. Hipple also pioneered microcapillary-based hematopoietic assays for human myelotoxicity testing of inves...

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