Genex Corporation

Gaithersburg, MD 20877

SBIR Award Summary

Total Number of Awards 9
Total Value of Awards $0.0
First Award Date 07/01/86
Most Recent Award Date 02/01/90

Key Personnel

Last Name Name Awards Contact
Filpula David R Filpula 1
Hardman Karl D Hardman 1
Fahnestock Stephen R Fahnestock 2
Bird Robert E Bird 1
Strausberg Robert L Strausberg 2
Whitlow Marc D Whitlow 1
Lee Timothy K Lee 1

9 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/90 - 08/31/90

DESCRIPTION: (Adapted from Investigator's Abstract) A Single-Chain Antibody protein with specificity for human IgM will be prepared. The SCA protein will be designed from a variable of the anti-human IgM monoclonal antibody, DA4.4. A gene to synthesize this protein will be constructed and the protein expressed in E. coli. The protein will be...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/89 - 06/30/90

The objective of the proposed research is to engineer the structure of anti-fluorescein (anti-FL) single chain antigen binding (SCA TM) proteins for improved stability and modification of binding affinity and specificity. In Phase I, Genex developed an SCA protein against the hapten fluorescein because the binding of this antigen can be easily ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/89 - 08/31/90

The objective of the proposed research is to develop an efficient microbial process for commercial production of adhesive proteins with properties similar to the adhesive protein of the mussel Mytilis edulis. Unlike most adhesives, this strong adhesive car set and adhere to surfaces in wet environments. It should also be nontoxic. Thus, it is...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/88 - 06/30/89

The objective of the proposed research is to develop an efficient microbial process for commercial production of adhesive proteins with properties similar to the adhesive protein of the mussel Mytilis edulis. Unlike most adhesives, this strong adhesive car set and adhere to surfaces in wet environments. It should also be nontoxic. Thus, it is...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/15/88 - 09/15/88

Gene fusions have been constructed that promote the efficient secretion of human serum albumin (HSA) from Bacillus subtilis. HSA-encoding sequences are fused to promoter and secretion signal-encoding sequences derived from B. amyloliquefaciens alpha-amylase (amy) and neutral protease (npr) genes. However, secretion is efficient only when the le...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/15/88 - 07/14/88

Using its proprietary protein engineering technology Genex has designed and produced a novel antigen-binding protein. The DNA sequences for the heavy (H) and light (L) chains of a monoclonal antibody to bovine growth hormone (BGH) have been cloned at Genex and modified to encode the antigen-binding fragment i.e., the Fv fragment, as a single po...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/15/88 - 07/14/88

Genex scientists have developed proprietary technology for the design of genes which code for the variable regions of antibody molecules linkded by polypeptide linkers. The genes code for both VL and VH regions and the resulting protein is synthesized as a single polypeptide chain in E. coli. After purification and refolding the single-chain a...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/01/87 - 06/30/87

Bacillus subitilis is an advantageous host organism for the production of foreign proteins at low cost because it has the capacity to secrete proteins into the growth medium at high levels. Several proteins of bacterial origin encoded by plasmid- borne recombinant genes have been secreted by B. subtilis strains at high levels. B. subtilis can ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/86 - 12/14/86

The objective of the proposed research is to develop an efficient microbial process for commercial production of a polyphenolic protein adhesive similar to that produced by the mussel Mytilis edulis. Unlike most adhesives, this strong adhesive can set and adhere to surfaces in wet environments. Thus, it is likely to have application in dental ...