Advanced Magnetics, Inc.

Cambridge, MA 02138

SBIR Award Summary

Total Number of Awards 10
Total Value of Awards $0.0
First Award Date 07/01/86
Most Recent Award Date 07/27/99

Key Personnel

Last Name Name Awards Contact
Groman Ernest V Groman 1
Enriquez Philip Enriquez 1
Josephson Lee Josephson 4
Paul Kenneth Paul 1
Lewis Jerome M Lewis 3

10 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/27/99 - 06/30/00

The goal is to develop a noninvasive MRI technique using colloidal magnetite contrast agents for sentinel lymph node (SLN) mapping and staging with application to melanoma and breast cancer patients. Peritumoral injections of these magnetite nanoparticles would limit their distribution to the lymphatic drainage basin near the primary tumor. Appl...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/92 - 03/31/93

The ultimate goal of this research is the development of tissue specific, or directed magnetic resonance imaging (MRI) contrast agents. These agents will consist of peptides attached to small, biodegradable superparamagnetic iron oxide colloids. The biodistribution of the superparamagnetic iron oxide label will be determined by the peptide on ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/92 - 03/31/93

The object of this research proposal is to develop an anti-hepatitis B virus pro-drug which will concentrate in the infected liver tissue by binding the hepatic asialoglycoprotein receptor and release the active form of the drug in the hepatocyte. Toward this end, a number of adenosine arabinofuranoside/arabinogalactan conjugates will be synthe...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/91 - 06/30/92

Diseases of the liver are a major world wide health problem, yet current diagnostic tests have shortcoming in assessing the functional hepatocyte mass of an individual. In our Phase I research, we developed an MR contrast agent which exhibited hepatocyte specific (liver specific) biodistribution, by virtue of its recognition by asialoglycoprotei...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/90 - 06/30/91

Diseases of the liver are a major world wide health problem, yet current diagnostic tests have shortcoming in assessing the functional hepatocyte mass of an individual. In our Phase I research, we developed an MR contrast agent which exhibited hepatocyte specific (liver specific) biodistribution, by virtue of its recognition by asialoglycoprotei...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/89 - 05/31/90

Efforts to enhance the usefulness of magnetic resonance imaging (MRI) in clinical medicine can involve the use of contrast agents. In Phase 1, we identified a ferrite based material which can be used to enhance the detection of hepatic tumors by MRI. We further established that the ferrite based agent was highly detectable by MR and biodegradab...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/88 - 02/28/89

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/88 - 05/31/89

Efforts to enhance the usefulness of magnetic resonance imaging (MRI) in clinical medicine can involve the use of contrast agents. In Phase 1, we identified a ferrite based material which can be used to enhance the detection of hepatic tumors by MRI. We further established that the ferrite based agent was highly detectable by MR and biodegradab...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/15/87 - 02/29/88

A number of syntheses of small magnetic particles permitting the covalent attachment of antibodies will be examined. Changes in magnetic resonance (MR) proton relaxation after magnetic antibodies have bound to cell surface antigens will be utilized to demonstrate the binding of antibody (and magnetic label) to antigens. The magnetic labels inv...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/86 - 12/31/86

As part of a collaborative effort with the Department of Radiology at the Massachusetts General Hospital, we intend to assess the potential of liver-targeted, ferrite-based contrast agents to enhance the potential of magnetic resonance (MR) imaging for detection of liver metastases using a rat tumor model. Although published studies to date wit...

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