Peptide Technologies Corporation

Gaithersburg, MD 20877

SBIR Award Summary

Total Number of Awards 9
Total Value of Awards $0.0
First Award Date 07/22/85
Most Recent Award Date 05/01/93

Key Personnel

Last Name Name Awards Contact
Burke Terrance R Burke 3
Knight Martha Knight 6

9 Awards Won

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/93 - 04/30/94

As an aid in the search for effective drugs against the HIV-1 virus that causes AIDS, a convenient radiopeptidase assay is proposed to be used in the screening for inhibitors of this enzyme responsible for infectivity. The HIV-1 aspartyl proteinase, one of the 3 functional enzymes of the retrovirus, clips the translated gag-pol polypeptide (vira...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/92 - 09/30/92

DESCRIPTION: (Adapted from the Applicant's Abstract): Recent bombesin and gastrin releasing peptide receptor antagonists have been demonstrated to be quite potent in inhibiting the effects of bombesin in pancreatic acinar cells, brainmembranes, Swiss 3T3 fibroblasts, and human small cell lung carcinoma (SCLC). However, these antagonists do no...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/89 - 02/28/90

Endothelin, a potent vasoactive peptide, has just been discovered as the formerly described endothelial cell-derived contracting factor involved in the regulation of vascular tone. Although endothelin possesses potent vasoconstricter activity in vitro, its actions in vivo appear to be complex. In the systemic and renal vascular beds vasodilati...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/88 - 08/31/89

The antibiotic viscosin, a cyclic depsipeptide isolated from Pseudomonas viscosa, shows promising in vitro and in vivo (mice) cytotoxicity against Trypanosoma cruzi, the causative agent in Chagas' disease. The total synthesis of viscosin, undertaken in Phase I, will be completed to confirm its structure. The synthetic methods utilized during t...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/88 - 01/31/89

A new countercurrent chromatography instrument, the cross-axis flow-through coil planet centrifuge is proposed for the preparative chromatography of peptides. This is an apparatus that separates substances according to their partitioning in a liquid-liquid equilibration system without the use of a solid-phase support. The instrument will be te...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/87 - 08/31/88

The antibiotic viscosin, a cyclic depsipeptide isolated from Pseudomonas viscosa, shows promising in vitro and in vivo (mice) cytotoxicity against Trypanosoma cruzi, the causative agent in Chagas' disease. The total synthesis of viscosin, undertaken in Phase I, will be completed to confirm its structure. The synthetic methods utilized during t...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/15/86 - 03/14/87

Bombesin is a gastrointestinal hormone and neurally active peptide. It stimulates gastric acid secretion via gastrin release. The peptide is behaviorally active in suppressing food intake and lowers body temperature. The mammalian endogenous form of the peptide is ectopically produced in small cell carcinoma of the lung. These tumor cells al...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 03/01/86 - 08/31/86

The antibiotic viscosin, a cyclic depsipeptide isolated from Pseudomas viscosa, shows promising in vitro and in vivo (mice) cytotoxicity against Trypanosoma cruzi, the causative agent in Chagas' disease. The total synthesis of viscosin is proposed in order to confirm the chemical structure and provide material for research. The methods develop...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/22/85 - 03/31/86

The syntheses of 19 cholecystokinin-octapeptide analogues are proposed. The preparation of these peptides will involve solid-phase techniques and purification on a new instrument for counter-current chromatography, the horizontal flow-through coil planet centrifuge. The binding of these peptides to cholecystokinin central nervous system and pan...