Neurex Corporation

Menlo Park, CA 94025

SBIR Award Summary

Total Number of Awards 10
Total Value of Awards $0.0
First Award Date 09/30/86
Most Recent Award Date 08/01/96

Key Personnel

Last Name Name Awards Contact
Bailey Richard B Bailey 1
Jakobovits Edward Jakobovits 1
Ramachandran Janakiraman Ramachandran 5
Pulliam Lynn Pulliam 1
Bowersox Stephen S Bowersox 1
Newcomb Robert W. Newcomb 1

10 Awards Won

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/96 - 07/31/97

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/96 - 02/28/97

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/95 - 07/31/95

The primary objective of this proposal is to develop pharmacological agents that inhibit neuronal programmed cell death (apoptosis). Techniques in molecular biology will be combined with animal models of cerebral ischemia to characterize the molecular mechanisms underlying neuronal apoptosis, and to evaluate the effects of potential therapeu...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/92 - 05/31/93

Opioids cause multiple physiological effects. Several distinct opioid receptors have been described, but their genes remain unknown. We propose to identify and clone opioid receptor genes to deduce their amino acid sequences and transfect the genes into mammalian cells. We have identified a human neuroblastoma cell line, SK-N-SH-SY5Y, which e...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/91 - 05/31/92

Opioids cause multiple physiological effects. Several distinct opioid receptors have been described, but their genes remain unknown. We propose to identify and clone opioid receptor genes to deduce their amino acid sequences and transfect the genes into mammalian cells. We have identified a human neuroblastoma cell line, SK-N-SH-SY5Y, which e...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/91 - 07/31/91

DESCRIPTION: (Adapted from the applicant's abstract) The long term objective of this application is to elucidate the structural and functional diversity of neuronal voltage-sensitive calcium channels (VSCC) by molecular cloning and expression of the channel proteins. Availability of pure subtypes of neuronal VSCC is crucial to the development ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/90 - 10/31/90

The biochemical basis for stress induced diseases, such as immunosuppression, inhibition of growth, neuronal degeneration and skeletal muscle atrophy and for neuropsychiatric disorders such as amnesia and Alzeheimer's disease are poorly understood. Adrenocorticotropic hormone (ACTH) and its receptor are essential molecular components in the per...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/89 - 01/31/90

Opioid peptides and drugs cause multiple effects in the CNS and throughout the entire body. Several distinct opioid receptors have been described biochemically and pharmacologically, but the genes encoding them remain unknown. We propose to identify and clone the opioid receptor genes and transfect each into mammalian cells. Because we have iden...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/89 - 01/31/90

Bladder incontinence is a functional disorder with growing consequences for the aging population. Current therapy includes drug treatment aimed at antagonizing the cholinergic input to the bladder. There are severe drawbacks to drug therapy primarily due to the lack of specificity of the drugs which result in side effects, many of which cannot...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/86 - 07/29/87

Enzymes that are L-glutaminases exhibit antitumor activity. Thus, work to develop these enzymes into therapeutic agents is in progress. Present limitations include the enzymes' substrate affinity, size, immunogenicity, and, in some cases, dual function as both L-glutaminase and L-asparaginase. The objective of this project is to obtain a sing...

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