Agouron Pharmaceuticals, Inc.

San Diego, CA 92121

SBIR Award Summary

Total Number of Awards 5
Total Value of Awards $0.0
First Award Date 08/01/85
Most Recent Award Date 08/01/90

Key Personnel

Last Name Name Awards Contact
Matthews David A Matthews 1
Welsh Katherine M Welsh 3
Ogden Richard C Ogden 1

5 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/90 - 12/31/91

The ultimate objective of this project is to utilize the information available in the three-dimensional crystal structure of an enzyme in the rational design of drugs which will be effective against Plasmodium falciparum. The specific enzyme target is the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of P. falciparum. The...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/89 - 07/31/90

The ultimate objective of this project is to utilize the information available in the three-dimensional crystal structure of an enzyme in the rational design of drugs which will be effective against Plasmodium falciparum. The specific enzyme target is the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of P. falciparum. The...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/88 - 09/30/88

The ultimate objective of this project is to utilize the information available in the three-dimensional crystal structure of an enzyme in the rational design of drugs which will be effective against Plasmodium falciparum. The specific enzyme target is the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of P. falciparum. The...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/86 - 01/31/87

Major objectives of the proposed research are to isolate 100 mg of homogeneous dihydrofolate reductase (DHFR) from Candida albicans, crystallize the enzyme and determine its three-dimensional structure using x-ray diffraction methods. Armed with the resulting detailed knowledge of the geometrical and topographical properties of Candidas DHFR in...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/85 - 02/28/86

Immunological and DNA hybridization assays which employ specific antibody and DNA probes are proving to be very valuable in the identification of pathogens and in the diagnosis of genetic diseases. The objective of this project is to improve the sensitivity, safety, and convenience of diagnostic tests by developing a non-radioactive, luciferase...