Zymogenetics, Inc.

Seattle, WA 98105

SBIR Award Summary

Total Number of Awards 10
Total Value of Awards $0.0
First Award Date 05/01/85
Most Recent Award Date 09/01/88

Key Personnel

Last Name Name Awards Contact
Kindsvogel Wayne R Kindsvogel 1
Hagen Frederick S Hagen 5
Murray Mark J Murray 2
Forstrom John Forstrom 1
Foster Donald C Foster 1

10 Awards Won

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/88 - 08/31/89

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/88 - 06/30/89

Human Protein C is a vitamin-K dependent plasma protein which is involved in the control of blood coagulation and fibrinolysis. An expression system for the production of recombinant human protein C has been established. This system is based on mammalian cells in culture, stably transfected with a DNA construction expressing human Protein C. ...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/87 - 08/31/88

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/87 - 01/31/88

Bile salt-activated lipase (BSAL) is found in the milk of a limited number of mammals: humans, gorillas, dogs, and cats. The enzyme plays an important role in the infant diet in the digestion of lipids and, as such, effects a striking quantitative difference between breast-fed and formula-fed infants in weight gain; in this regard, it is impor...

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/87 - 06/30/88

Human Protein C is a vitamin-K dependent plasma protein which is involved in the control of blood coagulation and fibrinolysis. An expression system for the production of recombinant human protein C has been established. This system is based on mammalian cells in culture, stably transfected with a DNA construction expressing human Protein C. ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 01/01/87 - 06/30/87

The goal of the project is the development of a commercially feasible system for the production of the human equivalent of interleukin-3 (IL-3) for use as a therapeutic agent in the treatment of patients whose hematopoiesis has been suppressed as a result of chemo- or radiation therapy or who are recovering from bone marrow transplantation. In ...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/86 - 11/30/86

The goal of this project is to create a stable murine myeloma cell line which secretes a human antibody against anthrax exotoxin. The molecular cloning of human immunoglobulin (Ig) genes from the genomic DNA of a human/mouse hybridoma is proposed. The human Ig genes, which encode an antibody against anthrax exotoxin, will be spliced to previou...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/86 - 09/30/86

A full length coding sequence for human protein C will be cloned. This will be done either by obtaining a 5' end clone from a liver cDNA library or by fusing genomic DNA sequence to our cDNA which lacks amino-terminal coding sequence. Once this clone is complete it will be introduced into an expression vector designed for high level expression...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/85 - 02/28/86

The goal of the project is the development of a commercially feasible system for the production of human granulocyte-macrophage colony stimulating factor (GmCSF) for use as a therapeutic agent in the treatment of patients whose immune system has been suppressed as a result of treatment with radiation therapy or chemotherapeutic agents. In Phase...

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/01/85 - 10/31/85

Methods are being investigated to increase the efficacy of producing monoclonal antibodies to trace quantities of peptides and proteins that are of high value to science and industry. The research will lead to the development of diagnostic and therapeutic antibodies having characteristics superior to those currently available. Submicrogram lev...

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