Awards

$163K

Aptamer-based Insulin Detection Device

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-096
Budget: 05/01/12 - 04/30/13
PI: Dr. Ralph Ballerstadt

DESCRIPTION (provided by applicant): The objective of the phase I proposal is to demonstrate the feasibility of a new and innovative insulin assay for its integration in a small benchtop device with the focus in clinical diabetes therapy: A) for assessment of insulin impairment in type II diabetics, and B) as feedback control for diabetics with ...

$537K

Platform for Massively Parallel Selection of Aptamer Ligands

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-096
Budget: 09/26/11 - 08/31/12
PI: George W Jackson

DESCRIPTION (provided by applicant): Aptamers have emerged as one of the most promising classes of drug leads and diagnostic ligands presently available. Aptamers, nucleic acid ligands derived from large combinatorial libraries, typically have affinities and specificities that rival antibodies, yet they have a number of significant advantages f...

$150K

Laser Catheter for Bronchial Treatment of Severe Asthma

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-10-050
Budget: 09/01/11 - 05/31/12
PI: Roger J Mcnichols

DESCRIPTION (provided by applicant): Asthma afflicts as many as 39 million Americans and some 4,000 will die of the disease each this year. The goal of this Phase I SBIR proposal is to design, develop, build, and test a novel, cooled laser catheter for effecting Bronchial Thermoplasty in a safe and efficient manner. Bronchial Thermoplasty is a r...

$242K

Assay for Monitoring Glycemic Control in Diabetics

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: RFA-DK-09-001
Budget: 09/01/10 - 08/31/12
PI: Dr. Ralph Ballerstadt

DESCRIPTION (provided by applicant): Diabetes is currently believed to afflict over 100 million people worldwide and nearly 18 million in the United States. In the U.S. this disorder, along with its associated complications, is ranked as the seventh leading cause of death. To significantly improve diabetes management, there is an urgent need for...

$108K

Endoscopic Tool for Small Animal Intubation

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-080
Budget: 09/01/10 - 02/28/11
PI: Seifu Teferra

DESCRIPTION (provided by applicant): The importance of in vivo small animal research to the scientific community cannot be overestimated. Along with the advantages of small animal manipulations come inherent difficulties, among them intubations which are often necessary for inhalation anesthesia. In small animals, placing endotracheal tubes is t...

$424K

5-Day Fiber-Coupled Fluorescense Sensor for Interstitial Glucose Monitoring

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-08-050
Budget: 09/01/10 - 08/31/12
PI: Dr. Ralph Ballerstadt

DESCRIPTION (provided by applicant): There is an urgent need for a long-term in vivo glucose-monitoring device for diabetes therapy. Diabetes is currently believed to afflict over 100 million people worldwide and nearly 18 million in the United States. In the U.S. this disorder, along with its associated complications, is ranked as the seventh l...

$151K

Local Hyperthermia Catheter for Enhanced Ablation and Cancer Therapy

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-09-080
Budget: 09/01/10 - 02/28/12
PI: Ashok Gowda

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR Grant Proposal is to develop a new device and methodology for local elevation of a target tissue's temperature prior to a planned thermal ablation, a process we've dubbed "hyperablation". In preliminary work we demonstrated that raising the pre-treated temperature of a target tis...

$209K

Rapid Microbial Identification by MALDI-TOF Mass Spectrometry of Ribosomal RNA

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-08-050
Budget: 04/19/10 - 02/28/11
PI: George W Jackson

DESCRIPTION (provided by applicant): The World Health Organization estimates that over 1,600 people die each hour from an infectious disease, half of whom are children under 5 years of age. Infectious diseases account for 26 percent of total global mortality and are the third leading cause of death in the United States. In addition to microbial ...

$326K

Rapid Microbial Identification by MALDI-TOF Mass Spectrometry of Ribosomal RNA

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-08-050
Budget: 03/01/10 - 02/28/12
PI: George W Jackson

DESCRIPTION (provided by applicant): The World Health Organization estimates that over 1,600 people die each hour from an infectious disease, half of whom are children under 5 years of age. Infectious diseases account for 26 percent of total global mortality and are the third leading cause of death in the United States. In addition to microbial ...

$365K

5-Day Fiber-Coupled Fluorescense Sensor for Interstitial Glucose Monitoring

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-08-050
Budget: 09/25/09 - 08/31/10
PI: Dr. Ralph Ballerstadt

DESCRIPTION (provided by applicant): There is an urgent need for a long-term in vivo glucose-monitoring device for diabetes therapy. Diabetes is currently believed to afflict over 100 million people worldwide and nearly 18 million in the United States. In the U.S. this disorder, along with its associated complications, is ranked as the seventh l...

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