Awards

$300K

Senescence-Chips for Radiation Biodosimetry

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-12-044
Budget: 08/05/14 - 07/31/15
PI: Daojing Wang

Project Summary/Abstract Ideal biomarkers of acute and delayed radiation injury after a radiological/nuclear terrorist incident are those that arise and are measurable prior to manifestation of tissue injuries, typically one to a few days after ionizing radiation (IR) exposure. They should also be measurable in a non-invasive or minimally invasi...

$350K

AD-MS Chips for Biofluids-Based Diagnosis of Alzheimer's Disease

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-335
Budget: 08/01/14 - 04/30/15
PI: Daojing Wang

DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is a devastating neurodegenerative disease that affects more than 35 million people (including 5 million Americans) worldwide, and this number is expected to reach more than 115 million by the year 2050. Recent disappointing clinical trials of bapineuzumab and solanezumab in AD treatm...

$225K

Ultrahigh-throughput Identification of Molecular Targets of Natural Products

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: RFA-AT-14-001
Budget: 06/01/14 - 11/30/14
PI: Daojing Wang

DESCRIPTION (provided by applicant): Natural products are rich sources for potential drugs. To accelerate drug discovery from natural products, it is imperative to identify their molecular targets, and mechanistically elucidate their bioavailability, toxicity, and therapeutic effects. However, there remain several challenges in the field. Among ...

$342K

Picoelectrospray Ionization Mass Spectrometry for Top-down Proteomics

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: PA-11-215
Budget: 05/01/14 - 04/30/15
PI: Daojing Wang

Project Summary/Abstract The proteome reflects the physiology and pathology states of a patient therefore proteomics is a powerful tool for early diagnostics of diseases and monitoring of therapeutic responses. Mass spectrometry (MS) measures the mass-to-charge ratio of charged species and has become the enabling technology for proteomics. Howev...

$225K

Omics-Based Assays for Screening Chemical Toxicity Using Stem Cells

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: RFA-ES-13-003
Budget: 09/12/13 - 08/31/14
PI: Daojing Wang

Project Summary/Abstract There is a paradigm shift in testing and modeling of chemical toxicity. Current toxicology calls for human-cell- based (vs. animal-based), evidence-based, and Omics-based assays. Mesenchymal stem cells (MSC) play important roles in the maintenance and repair of various tissues, including bone, cartilage, and muscle. MSCs...

$250K

Microfluidic Chips for Biomonitoring

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic: RFA-ES-12-004
Budget: 09/20/12 - 08/31/13
PI: Pan Mao

DESCRIPTION (provided by applicant): One of the most exciting developments in environmental science and technology is the emerging field of "exposomics", i.e., rapid and sensitive detection of large sets of analytes ("exposome") reflecting the complexity of exposure in the personal environment using human specimens including blood, urine, and sa...