Awards

Unknown

Nonpeptide Inhibitors of Anthrax Lethal Factor

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/01/99 - 05/31/00
PI: Darryl C Rideout

DESCRIPTION (Adapted from the application): This is a proposal to develop inhibitors of the lethal factor (LF) zinc protease that is responsible for the deadly effects of Anthrax. The Structural Bioinformatics group intend to use homology modeling and Monte Carlo simulations to develop structural models and consens...

Unknown

Small Molecule Her2 Inhibitor Discovery

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/99 - 09/30/99
PI: Christina C Niemeyer

DESCRIPTION (Adapted from the application): The HER2 (erbB2, neu) gene encodes a transmembrane tyrosine protein, a member of the epidermal growth factor receptor family which is amplified and over expressed in nearly 30% of human cancers. HER2 is associated with poor prognosis, chemoresistance, and aggressive and metastatic tumor growth. This ye...