Phase 1 SBIR
DESCRIPTION (Adapted from the application): This is a proposal to develop inhibitors of the lethal factor (LF) zinc protease that is responsible for the deadly effects of Anthrax. The Structural Bioinformatics group intend to use homology modeling and Monte Carlo simulations to develop structural models and consens...
Phase 1 SBIR
DESCRIPTION (Adapted from the application): The HER2 (erbB2, neu) gene encodes a transmembrane tyrosine protein, a member of the epidermal growth factor receptor family which is amplified and over expressed in nearly 30% of human cancers. HER2 is associated with poor prognosis, chemoresistance, and aggressive and metastatic tumor growth. This ye...
