Awards

$375K

Development of Sub-second 3D Pulse Sequences for FMRI in Neurosciences

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-07-389
Budget: 03/01/10 - 02/28/13
PI: David Alan Feinberg

DESCRIPTION (provided by applicant): MRI is a proven non-invasive technique to make functional MRI (fMRI) by measuring changes in "blood oxygen level dependent" (BOLD) contrast in different regions of the brain resulting from the neurovascular coupling of neuronal activity. Echo planar imaging (EPI) is the most widely used fMRI pulse sequence, d...

$412K

Cerebral Perfusion Imaging with 3D Arterial Spin Labeling GRASE MRI

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-046
Budget: 04/01/09 - 03/31/12
PI: David Alan Feinberg

DESCRIPTION (provided by applicant): Arterial spin labeling (ASL) has proven its ability to non-invasively measure cerebral blood flow (CBF). However, widespread use of this promising technique has been prevented by its long acquisition time due to the inherently image low signal-to-noise ratio (SNR). Recently, it has been shown that the use of...

$375K

Development of Sub-second 3D Pulse Sequences for FMRI in Neurosciences

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-07-389
Budget: 03/01/09 - 02/28/10
PI: David Alan Feinberg

DESCRIPTION (provided by applicant): MRI is a proven non-invasive technique to make functional MRI (fMRI) by measuring changes in "blood oxygen level dependent" (BOLD) contrast in different regions of the brain resulting from the neurovascular coupling of neuronal activity. Echo planar imaging (EPI) is the most widely used fMRI pulse sequence, d...

$100K

Development of Sub-second 3D Pulse Sequences for FMRI in Neurosciences

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-07-89
Budget: 09/15/08 - 02/28/09
PI: David Alan Feinberg

DESCRIPTION (provided by applicant): MRI is a proven non-invasive technique to make functional MRI (fMRI) by measuring changes in "blood oxygen level dependent" (BOLD) contrast in different regions of the brain resulting from the neurovascular coupling of neuronal activity. Echo planar imaging (EPI) is the most widely used fMRI pulse sequence, d...

$353K

Cerebral Perfusion Imaging with 3D Arterial Spin Labeling GRASE MRI

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-46
Budget: 04/01/08 - 03/31/09
PI: David Alan Feinberg

DESCRIPTION (provided by applicant): Arterial spin labeling (ASL) has proven its ability to non-invasively measure cerebral blood flow (CBF). However, widespread use of this promising technique has been prevented by its long acquisition time due to the inherently image low signal-to-noise ratio (SNR). Recently, it has been shown that the use of...

$153K

Cerebral Perfusion Imaging with 3D Arterial Spin Labeling GRASE MRI

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic: PA-06-46
Budget: 08/01/07 - 03/31/08
PI: David Alan Feinberg

DESCRIPTION (provided by applicant): Arterial spin labeling (ASL) has proven its ability to non-invasively measure cerebral blood flow (CBF). However, widespread use of this promising technique has been prevented by its long acquisition time due to the inherently image low signal-to-noise ratio (SNR). Recently, it has been shown that the use of...

$375K

Ultrasound-guided MRI

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/15/05 - 06/14/07
PI: David Alan Feinberg

DESCRIPTION (provided by applicant): Despite new rapid image acquisition techniques high-quality MRI data requires data collection times of several seconds or minutes. Any kind of uncompensated object movement on this time scale will lead to blurring, ghosting or other artifacts in the resulting images. All currently available motion correcti...

$365K

Improved 3D MRI with cylindrical trajectories

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/08/04 - 09/30/06
PI: David Alan Feinberg

DESCRIPTION (provided by applicant): We are proposing the development of a family of 3D single-slab MRI pulse sequences based on interleaved cylindrical k-space trajectories. Spin-echo-train and gradient-echo versions will be implemented on a state-of-the-art commercially available whole-body MR scanner equipped with high-performance gradients. ...

$375K

Ultrasound-guided MRI

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/15/04 - 06/14/05
PI: Joerg M Guenther

DESCRIPTION (provided by applicant): Despite new rapid image acquisition techniques high-quality MRI data requires data collection times of several seconds or minutes. Any kind of uncompensated object movement on this time scale will lead to blurring, ghosting or other artifacts in the resulting images. All currently available motion correcti...

$368K

Improved 3D MRI with cylindrical trajectories

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/08/03 - 09/07/04
PI: Kai Ruppert

DESCRIPTION (provided by applicant): We are proposing the development of a family of 3D single-slab MRI pulse sequences based on interleaved cylindrical k-space trajectories. Spin-echo-train and gradient-echo versions will be implemented on a state-of-the-art commercially available whole-body MR scanner equipped with high-performance gradients. ...

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