Awards

$99.8K

New Treatment for Inflammation in Middle Ear Infections

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 12/15/02 - 06/14/03
PI: Stephen E. Kurtz

DESCRIPTION (provided by applicant): Otitis media with effusion (OME) is one of the most prevalent inflammatory diseases in the pediatric population, and is associated with pain and hearing loss. OME is characterized by release of inflammatory mediators and enzymes such as pro-inflammatory cytokines, cellular infiltration into the middle ear, an...

$99.8K

New Therapy for Cystic Fibrosis Dna-induced Inflammation

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/20/01 - 10/19/01
PI: Sharon L Mccoy

DESCRIPTION (Adapted from the Investigator's Abstract): Cystic fibrosis (CF) is the most common lethal genetic disease in North America, affecting one in every 2500 individuals. Most of the morbidity and over 90 percent of the mortality results from chronic progressive inflammation of the lungs. Current therapies have pr...

Unknown

Gene Delivery by a Cell Surface DNA Binding Protein

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/97 - 09/29/98
PI: Louise S Merkens

Gene transfer therapy offers the potential for treatment of a variety of diseases. Naked plasmid DNA has been successfully used for both gene therapy and vaccine development. The mechanism mediating the binding and internalization of plasmid DNA by cells leading to gene expression remains undefined, Base...