Awards

Unknown

Indolocarbazole Topoisomerase I Poisons/antitumor Agents

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/97 - 12/31/97
PI: David E Zembower

Two semi-synthetic indolocarbazole derivatives, ED-11O and NB- 506, have been described as potent inhibitors of topoisomerase I, an enzyme critical for cell viability and an important target for anticancer drug design. These analogues showed impressive in vitro and in vivo antitumor a...

Unknown

Synthesis of Quinolone Antihiv-1/hiv-2 Agents

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/97 - 09/30/97
PI: David E Zembower

3,5,8-Trihydroxy-4-quinoline (THQ), isolated from a marine sponge, and a semi-synthetic derivative, 5,8-dimethoxy-e-hydroxy-4-quinolone (6), inhibited reverse transcriptase (RT) from HIV-1 and HIV-2, with IC50 values ranging from 2.4 to 43 muM. THQ interacted with a RT- DNA complex differently...

Unknown

Michellamine B Analogues as Antihiv-1/antihiv-2 Agents

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/96 - 01/31/97
PI: David E Zembower

Unknown

Synthesis of New Antihiv Agents Related to Calanolide a

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/01/96 - 03/31/97
PI: Michael T Flavin

Unknown

Novel Phosphonate Nucleotide Analogs as Antihiv Agents

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/95 - 05/31/96
PI: Ze-Qi Xu

Unknown

Antihiv Drugs From Blumea Aromatica and Blumea Riparia

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 09/01/95 - 02/29/96
PI: Yuh-Meei Lin

Unknown

Synthesis of Novel Acyclonucleotides as Antihiv Agents

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/10/95 - 02/09/96
PI: Ze-Qi Xu

Unknown

Synthesis of New Antihiv Agents Related to Calanolide a

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/10/95 - 03/31/96
PI: Michael T Flavin

DESCRIPTION: The principal investigator notes that the recently discovered class of remarkably effective anti-HIV natural products known as the calanolides are extremely difficult to obtain from natural sources. He reports that in his Phase I work, he has completed the total synthesis of racemic calanolide A, the most potent of the com...

Unknown

Isolation of Antihiv Agents From Siegesbeckia Pubescens

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 04/10/95 - 10/10/95
PI: Yuh-Meei Lin

Unknown

Synthesis of the Novel Anti-hiv Agent Calanolide a

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 08/15/93 - 02/15/94
PI: William Boulanger

The recently discovered class of remarkably effective anti-HIV-1 natural products known as the calanolides are extremely difficult to obtain from natural sources. We herein propose a total synthesis of calanolide A, the most potent of the compounds reported. What is proposed is more than a natural product synthesis. It is necessary to develop...

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