Awards

Unknown

Hplc Receptor Phases as Combinatorial Screens

Phase 2 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/99 - 06/30/00
PI: Irving W Wainer

DESCRIPTION: (Adapted from the applicant's abstract) Combinatorial methods for the synthesis of new drug substances require high throughput techniques for evaluation of structure-activity relationships. Microtiter plates with immobilized target receptors can rapidly reduce thousands of possibilit...

Unknown

Isoquinoline B3 Ar Agonists as Antiobesity Agents

Phase 2 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/98 - 06/30/99
PI: Dennis Rudolph Feller

DESCRIPTION (Adapted from the application): More than one-third of Americans are overweight (obese), and it is important to identify new therapeutic treatments for this condition. A number of approaches include liquid diets, calorie counting, fat counting, commercial weight loss programs, and the ...

Unknown

Isoquinoline B3 Ar Agonists as Antiobesity Agents

Phase 2 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/98 - 06/30/99
PI: Dennis Rudolph Feller

DESCRIPTION (Adapted from the application): More than one-third of Americans are overweight (obese), and it is important to identify new therapeutic treatments for this condition. A number of approaches include liquid diets, calorie counting, fat counting, commercial weight loss programs, and the ...

Unknown

Hplc Receptor Phases as Combinatorial Screens

Phase 2 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 07/01/98 - 06/30/99
PI: Irving W Wainer

DESCRIPTION: (Adapted from the applicant's abstract) Combinatorial methods for the synthesis of new drug substances require high throughput techniques for evaluation of structure-activity relationships. Microtiter plates with immobilized target receptors can rapidly reduce thousands of possibilit...

Unknown

Hplc Receptor Phases as Combinatorial Screens

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 08/01/97 - 01/31/98
PI: Irving W Wainer

DESCRIPTION: (Adapted from the applicant's abstract) Combinatorial methods for the synthesis of new drug substances require high-throughput techniques for evaluation of structure-activity relationships. Microtiter plates with immobilized target receptors can rapidly reduce 1000's of possibilities to 100's ...

Unknown

Isoquinoline Beta3-ar Agonists as Antiobesity Agents

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 12/15/96 - 05/31/97
PI: Duane D Miller

More than 1/3 of Americans are overweight (obese), and it is important to identify new therapeutic treatments for this condition. A number of approached include liquid diets, calorie counting, fat counting, commercial weight loss programs, and the use of drugs. In the 1960's and 1970's amphetamines...

Unknown

Novel 9-cis Retinoids:design Synthesis and Evaluation

Phase 1 STTR

Agency: Department of Health & Human Services
Topic:
Budget: 09/30/96 - 08/29/97
PI: Charles N Robinson

Unknown

Alpha Adrenergic Agonists for Cpr

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 06/15/94 - 12/14/94
PI: William Paul Purcell

In the United States alone, approximately 450,000 people yearly suffer a cardiac arrest outside the hospital. Less than 10% of these patients are discharged from the hospital alive, and of these, approximately 60% suffer some form of permanent neurologic injury. The poor resuscitation rates and neurologic outcome result in part from the low le...

Unknown

Topical Drugs for the Treatment of Psoriasis

Phase 2 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 02/01/92 - 01/31/93
PI: Harlie A Parish

Benoxaprofen is effective in the systemic treatment of psoriasis but is toxic. One of the goals of this application is to modify benoxaprofen for topical administration which should result in high concentrations at the lesion site, lower concentrations systemically, and improved safety. Thirteen compounds have been evaluated in the arachidonic...

Unknown

Development of Elastase Inhibitors to Treat Emphysema

Phase 1 SBIR

Agency: Department of Health & Human Services
Topic:
Budget: 05/07/91 - 11/06/91
PI: Harlie A Parish

The goal of this application is to develop a synthetic inhibitor of elastase that will be effective and safe in the treatment of emphysema. Two different laboratories reported that chloromethyl ketone (CMK) is effective in animal models of emphysema. However, the CMK are too toxic for human use. We have modified the structure of the CMK to re...

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