Online Urea Monitoring During Hemodialysis

Period of Performance: 02/01/1993 - 07/31/1993


Phase 1 SBIR

Recipient Firm

Anatrace, Inc.
Cleveland, OH 44128
Principal Investigator


Hemodialysis is prescribed for over 400,000 patients worldwide, often with little knowledge of the per treatment efficiency as related to the individual patients needs. A methodology and apparatus are proposed for the quantification of urea removal during treatment. A prototype urea sensor will be developed based on the marriage of immobilized enzyme and ion selective electrode technologies. The sensor design will allow continuous operation on-line in the dialysate stream. When adapted to a clinical setting (Phase II program) the concept as proposed will avoid the need for blood sampling.