Biomarkers for Occult Neural Infectious Disease

Period of Performance: 02/19/2009 - 08/19/2009


Phase 1 SBIR

Recipient Firm

Protein Express, Inc.
9940 Reading Rd
Evendale, OH 45241
Principal Investigator


Despite years of research, the etiology of senile dementia of the Alzheimer s type (AD) is still unknown. Infectious agents have never been ruled out, and our reliminary studies suggest that bacteria derived from AD brain slices cultured in our novel EBTKS medium may be involved. To identify these bacteria, brain slices will be cultured and non-human DNA sequences derived from the culture by massively parallel means. These sequences will permit (1) the determination of diagnostic PCR primer sets and (2) antigenic peptides that may be used to develop antibody-based diagnostic reagents.