Development of a Point-of-care Assay for the Detection of Rift Valley Fever Virus, a Militarily Important Pathogen of the CENTCOM and AFRICOM Area of

Period of Performance: 02/26/2009 - 08/25/2009

$69.9K

Phase 1 SBIR

Recipient Firm

Inbios International, Inc.
562 1st Ave S, Suite 600 Array
Seattle, WA 98104
Principal Investigator

Abstract

The objective of this study is to develop a robust, field grade, screening assay for the detection of RVFV in human blood and sera. The test will utilize a lateral flow (dipstick) chromatography incorporated into a cassette. The proposed immunochromatographic assay would be a very useful screening test to assess RVFV. This would facilitate the treatment of military personnel presenting with febrile illness. It would also help in eradication programs. In this Phase I study we will develop/acquire antibody and antigen reagents for use in development of prototype RVFV detection assays. We will then construct prototype assays that will be evaluated against archived samples from infected individuals. Further development of the assay would take place in a Phase II proposal.