High-Power Diode Laser Development for Rapid Sterilization of Medical Instruments and Hemostasis

Period of Performance: 07/30/1996 - 02/22/1998


Phase 2 SBIR

Recipient Firm

Spire Corp.
One Patriots Park
Bedford, MA 01730
Principal Investigator


This proposal outlines the development of a new, high power, high-reliability diode laser for use in rapid medical instrument sterilization and hemostasis. This new laser will be fabricated from aluminum-free InGaAsP material which has demonstrated superior laser-performance and lifetime characteristics. Building on its existing AlGaAs diode laser bar manufacturing technology, Spire will develop the growth of this new InGaAs P material and produce high power laser array modules. These high power lasers will be incorporated into an innovative, portable battlefield unit for rapid sterilization of medical instruments, and will also be investigated for emergency hemostasis applications. The basic building-block of these new diode laser arrays will be a robust, 1-cm wide diode laser bar which will be fabricated from InGaAsP wafers epitaxially grown in one of Spire's chemical vapor deposition systems. The cw output per1-cm wide bar is expected to be 40W, almost twice that produced by presently-available AlGaAs cw laser bars. The InGaAsP bar reliability is expected to be in the tens of thousands of hours. As an option Spire proposes to bring these reliable 40W InGaAsP laser bars to market as a commodity item. The Phase I program successfully achieved the objective of building and demonstrating a two-color, 690 nm / 800 nm, diode laser-based instrument for combined photodynamic therapy (PDT) and laser hyperthermia treatment of malignant tumors. Single-bar cw output power levels of 20W/bar at 800 nm were obtained. Using various photosensitizer doses on mice, a 96% reduction in tumor weight was observed for combined PDT/laser hyperthermia as compared to PDT alone. This success in the Phase I effort demonstrates Spire's growing expertise in the diode laser-based medical instrument technology.