On-Chip Transport of Biological Fluids in MEMS Devices

Period of Performance: 05/14/1997 - 05/14/1999


Phase 2 SBIR

Recipient Firm

CFD Research Corp.
701 McMillian Way NW Suite D
Huntsville, AL 35806
Principal Investigator


The proposed work will develop a highly integrated, experimentally validated, flexible CAD environment for the design analysis of complex biological/chemical MEMS devices and systems. The Phase I work demonstrated the proof-of-concept of using advanced computational models for analyzing non-Newtonian fluid flow in MEMS components such as microchannels, micromixers and microplumes. The non-Newtonian models developed in Phase I were validated against experimental data obtained at Pacific National Northwest Laboratory (PNNL). The Phase II work will focus on incorporating advanced models for biological/chemical MEMS into a flexible CAD environment to facilitate design simulations of devices and systems of devices. A comprehensive experimental study will be performed at PNNL to obtain benchmark validation data on biological fluids. The innovative aspect of the proposed work is that it offers a comprehensive suite of physical models (for flow, mixing, chemistry, electrophoresis, acoustic pumping, electromagnetic fields, fluid-structure interaction, free-surface flow and multi-phase transport) in a single environment with implicit coupling between the phenomena. This approach will ensure smooth and robust convergence of the code for stiffly coupled problems and also eliminates the need for linking widely different software for different disciplines. The integrated environment will also contain a virtual library of devices (for rapid systems assembly) and a MEMS knowledgebase consisting of rules and guidelines for optimizing the design process. Therefore, the proposed development will be an enabling technology for the simulation of Mixed Technology Systems-on-Chip (MT SOC). The model will be demonstrated (in collaboration with Baxter Healthcare, Lucas Novasensor, Berkeley Microinstruments and David Sarnoff Research Center) on industrial MEMS devices and systems.