Improving drug safety for pregnant women by delivering current and authoritative information via mobile devices

Period of Performance: 09/30/2017 - 09/29/2018

$500K

Phase 2 SBIR

Recipient Firm

Rightanswer.com, Inc.
Midland, MI 48641
Principal Investigator

Abstract

Project(Summary(/(Abstract( ! An!estimated!40,000!infants!delivered!annually!in!the!United!States!are!born!with!birth!defects!caused!by!the!use!of! medication!during!pregnancy.!!Since!the!peak!prevalence!of!some!diseases,!such!as!hypertension,!autoimmune!disease,! and!depression,!occurs!during!the!childbearing!years,!it!is!not!surprising!that!medication!use!during!pregnancy!is! common,!with!nine!out!of!ten!pregnant!women!in!the!United!States!taking!at!least!one!medication!to!treat!a!medical! condition.!!Although!recent!advances!in!technology!have!increased!access!to!health!care!information,!evidence-based! information!related!to!the!use!of!medications!during!pregnancy!can!be!difficult!to!find.!!Even!so,!much!of!the! information!that!is!available!is!inadequate!when!it!comes!to!prescribing!for!the!individual!patient,!or!it!is!not!easily! understood!or!evaluated!by!healthcare!providers!(HCPs)!who!lack!specialized!training!in!teratology.!!As!the!Center!for! Disease!Control!&!Prevention!notes,!a!few!databases!exist!that!provide!expert!review!and!interpretation!of!the!available! scientific!data!regarding!the!adverse!effects!of!medications!on!the!fetus,!but!these!resources!are!generally!available!by! subscription!only!and!thus!not!widely!available!to!HCPs!or!their!patients.!!As!a!result,!these!databases!are! ?underutilized.?!!This!dilemma!ultimately!impacts!two!vulnerable!patient!populations!?!pregnant!women!and!their! unborn!children.! ! To!address!this!dilemma,!RightAnswer!(http://www.rightanswer.com)!and!the!TERIS!team!at!the!University!of! Washington!have!collaborated!to!develop!a!specialized!mobile!application!that!presents!the!relevant!medication! information!in!a!format!that!is!both!easily!readable!and!searchable!in!novel!ways!relevant!to!the!end!users!knowledge! level.!!In!Phase!I!of!this!project,!167!HCPs!that!care!for!pregnant!women!were!surveyed!to!better!understand!their! current!practices!and!information!needs.!!Based!on!these!findings,!a!prototype!mobile!app!was!designed!that! consolidated!drug!information!across!multiple!sources!to!create!a!single!repository!that!included!patient!handouts!and! information!about!breastfeeding,!dosage,!and!alternative!medications.!!An!interface!was!created!to!allow!users!to! navigate!between!concise!and!detailed!summaries!of!the!research!findings.!!The!prototype!was!evaluated!by!22!HCPs! who!found!the!information!presented!to!be!valuable!and!the!app!easy!to!use.!! ! Using!what!was!learned!in!Phase!I,!the!Phase!II!plan!will!focus!on!two!goals:!!1)!continuing!to!improve!the!organization! and!presentation!of!data!to!support!diverse!querying!of!medical!options!and!2)!testing!mobile!app!models!on!a!large! scale!and!expanding!the!user!base!through!commercial!development.!!The!data!collected!in!Phase!I!will!provide! additional!insights!for!Phase!II!development!regarding!critical!data!for!different!clinical!settings!so!that!alternative!forms! of!delivery!can!be!explored,!including!import!into!existing!pharmacy!or!electronic!medical!record!systems!or!pre-loading! data!on!mobile!devices!for!environments!where!network!access!may!be!unavailable.!