Highly Accelerated Simultaneous Multi-Slice Phase Contrast MRI

Period of Performance: 08/01/2017 - 07/31/2018

$1.37MM

Phase 2 SBIR

Recipient Firm

Advanced MRI Technology, LLC
Sebastopol, CA 95472
Principal Investigator

Abstract

? DESCRIPTION (provided by applicant): MRI phase contrast velocity imaging is a widely disseminated on nearly all MRI scanners used for clinical diagnosis of brain disease, cardiac and cardiovascular disease and for neuroscience research. Currently phase contrast imaging of blood flow and CSF motion requires longer scan times with each 2D slice or 3D spatial image requiring additional dimension of velocity encoding requiring greater acquisition time. Given the physiological variation in heart rate, cardiac stroke output and respiratory motion effects on blood and CSF velocity, no less the need to greatly reduce the patients time in the scanner, there is a need to reduce the scan time of phase contrast imaging. To achieve several times faster imaging we propose to develop novel technology to acquire velocity phase images simultaneously instead of seperately. Our new technique called simultaneous multi-slice imaging (SMS) phase contrast (PC) imaging is innovated to obtain 2 -10 phase contrast images recorded simultaneously resulting in nearly this factor of reciprocal reduction in scan time. The availability of the new simultaneous phase contrast imaging technology will give clinicians and researchers the capability of performing significantly improved MRI perfusion measurements in the and these improvements will impact the diagnosis of many different diseases, including stroke, cardiac, cardiovascular diseases. Additionally blood flow and CSF flows which are important quantitative biomarkers useful as physiological imaging in evaluating new drug therapies for diseases. This family of new phase contrast imaging techniques utilizes more efficient pulse sequences that provide major advantages in resolution, slice coverage, SNR and speed. The new simultaneous imaging will have high utility and be highly desirable for use on clinical scanners worldwide. The improved quantitative MRI blood flow imaging offers overall increased speed that is highly commercializable given they provide improved diagnostic approaches to evaluate diseases and further improve specificity and sensitivity in MRI exams. The new technology will be designed, implemented and evaluated on MRI scanners at University of California Berkeley, University of California San Francisco (UCSF) Medical Center, Harvard Medical School, and Cedar-Sinai Medical Center. Once imaging protocols are optimized they will be further evaluated and optimized in collaborative clinical test sites in Europe, including the major cardiovascular hospital in London, the Royal Brompton Hospital and elsewhere. In addition to establishing their value in medical exams, the simultaneous phase contrast imaging will be made into useful tools for basic and clinical research.