STTR Phase I: Smartphone-based Slide Scanner for Mobile Digital Pathology

Period of Performance: 01/01/2017 - 12/31/2017

$225K

Phase 1 STTR

Recipient Firm

LiveFocus LLC
1251 Bunker Hill Blvd, Apt B
Columbus, OH 43220
Firm POC, Principal Investigator

Research Institution

The Ohio State University
1330 Kinnear Road
Columbus, OH 43212
Institution POC

Abstract

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to provide an affordable mobile digital pathology solution to pathologists in order to facilitate their clinical practices in disease diagnosis, peer consultations, tumor board preparations, research and education. The low-cost smartphone based portable pathology slide scanner is a complementary solution to current high throughput expensive digital pathology equipment to allow whole slide imaging to penetrate across all tiers of market. Given the high owning rate of mobile devices, the increasing processing and transmission speed, and the versatility of mobile apps, this device brings whole slide imaging at fingertips of individual pathologists. This greatly simplifies intra- and inter- institutional consultations and tumor board preparations, which enhances our fundamental understanding of disease causes and in turn leads to possible cures with improved clinical outcomes. The device also reduces the needs for physical transport of glass slides or tissue blocks to centralized digital imaging equipment. It also provides strong support on timely and accurate diagnosis, especially for those remote to digital imaging equipment. Moreover, this study provides an effective approach for teaching foundational skills of whole slide imaging to the next-generation pathologists. The proposed project is to validate the technical feasibility of using smartphone based portable slide scanner for acquiring pathological slide images with the optical performance comparable or close to those by commercial high-end slide scanners. This device is based on an innovative zoom-microscope design, where elastomer-liquid lenses with low optical aberration are used for changing the zoom ratio. This portable device can reach the optical magnification of 10X-40X and nearly diffraction-limited resolution with small lens diameters (