Development of new approaches to FTICR mass spectrometry

Period of Performance: 07/15/2016 - 07/14/2017

$150K

Phase 1 SBIR

Recipient Firm

MassTech, Inc.
COLUMBIA, MD 21046
Principal Investigator

Abstract

A significant increase in the mass resolving power of Fourier Transform Ion CyclotronResonance (FTICR) mass spectrometers broadly utilized for ion tissue imaging andproteomics studies will have a profound impact on the entire analytical field ofcharacterization of proteins, lipids, and metabolites. A 4-fold increase in the resolvingpower will create a unique analytical tool specifically applicable to the MS-based analysisof trace amounts of chemical and biological substances. We plan to build a platformcombining the multi-electrode ICR cell and novel signal amplification system with the goalto attain the most efficient usage of the FTICR systems with less expensive magnets thusmaking these instruments the top research tools in biological mass spectrometry. Takinginto account an availability of moderate-field FTICR systems in the laboratories, this willenable a wider use of these systems in the variety of the MS based analytical fields.