Nerve Agent Decontaminating Biocatalytic Polymers

Period of Performance: 12/21/1999 - 05/19/2002


Phase 2 SBIR

Recipient Firm

Agentase LLC
3636 Boulevard of the Allies, Suite B-17
Pittsburgh, PA 15213
Principal Investigator


The objective of this phase II research proposal is to develop a prototype enzyme-polymer fabric for the detoxification of surfaces contaminated with organophosphorus(op) nerve agents and potential use as a barrier to op exposure. Research activity will entail the optimization of materials developed during phase I, which includes studies on live agents. Enzymes to be incorporated within polymer foams incude alkaline phosphatase, cholinesterase, dfpase,and organophosphorus hydrolase and acid anhydrolase. Successful accomplishment of the specific aims of this phase II proposal will result in the development of a novel biomaterial having potential utility for armed services personnel, domestic preparedness agencies, and the pesticide and agriculturalindustries. Nerve agent degrading polmers will have broad-based utility for the us armed forces, the anti-terrorism domestic preparedness community, andthose industries employing op pesticides.