High-Throughput Low-Cost Manufacturing of Engineered MRI Contrast Agents

Period of Performance: 01/01/2015 - 12/31/2015


Phase 1 SBIR

Recipient Firm

Weinberg Medical Physics, LLC
Firm POC
Principal Investigator


Scalable manufacturing of micro-engineered MRI contrast agents has the potential to increase the specificity and resolution of imaging techniques, while reducing morbidity. Currently, techniques used for making such particles are expensive and labor intensive. In Phase I, Weinberg Medical Physics will validate techniques for rapid, massively parallel fabrication of microscale contrast agents (including shells, disks, and doubledisks). In order to demonstrate the utility of the proposed approach, they will build three different contrast agents (with shapes similar to those reported in NIST publications), demonstrate contrast agent monodispersity, mechanical stability (during processing steps typically encountered in clinical dose preparation), NMR shift uniformity, and feasibility of automated manufacturing.