Novel Therapeutic Approach to Hypercholesterolemia Using Next-Generation DNA Sequ

Period of Performance: 02/12/2014 - 11/30/2014

$218K

Phase 1 SBIR

Recipient Firm

Abeome Corporation
ATHENS, GA 30602
Principal Investigator

Abstract

DESCRIPTION (provided by applicant): We have developed and completed a proof-of-principle on a new transgenic mouse model for comprehensive characterization of the antibody repertoire made in response to ovalbumin injection using surface antibody capture and next-generation DNA sequencing technologies. A more commercially valuable proof is now sought using a novel screening method with an emerging drug target for hypercholesterolemia, known as PCSK9.