Pathogen Identification of Wounds Via Bead-Based Multiplexing

Period of Performance: 06/11/2013 - 11/15/2015

$1000K

Phase 2 SBIR

Recipient Firm

Areté Associates
9301 CORBIN AVE Suite 2000
Northridge, CA 91324
Principal Investigator

Abstract

Areté Associates and Luminex Corporation propose a Phase II SBIR effort to develop a portable, Point-of-Care system that enables rapid identification of known and de novo pathogens in wounds. The proposed system, which leverages Luminex s award-winning bead-based multiplexing technology and Areté s advanced bioinformatics algorithms, provides pathogen identification and antibiotic resistance information for targeted treatment. The proposed work builds on key results from Phase I, including: (a) proof-of-concept demonstration of an algorithmic technique to detect antibiotic resistance signatures that can be exploited for assay design, (b) feasibility demonstration of streamlined multiplex assays for wound pathogen identification with the ability to optionally add protein assays, and (c) establishment of a strong foundation for rapid multiplex cytokine and pathogen detection through an efficient, simple workflow with low levels of detection for both purified and complex (in-context) sample matrixes.