SBIR Phase I: Nano-enhanced Fibrous Structures for Pathogenic Virus Elimination from Biopharmaceutical Products

Period of Performance: 01/01/2009 - 12/31/2009

$100K

Phase 1 SBIR

Recipient Firm

Alditri Technologies
7520 Windmill Harbor Way, Apt 2302
Raleigh, NC 27617
Principal Investigator

Abstract

This Small Business Innovation Research Phase I project is an effort by Alditri Technologies, Inc. to nano-enhance fiber materials in order to capture parvoviruses. Specifically, Alditri will employ and seek to understand vapor-phase deposition technology as it applies to fiber materials to convert low-cost fiber materials into effective virus capture devices. Purification accounts for a large portion of biopharmaceutical product cost. Further, the extremely expensive parvovirus capture devices currently available are not suitable for large-scale operations, such as those involved in biomanufacturing streams. This work will build upon previous fundamental advances at Alditri regarding the nano-enhancement of nonwovens. The successful completion of this project will result in low-cost, efficient parvovirus removal membranes for use in aqueous streams such those in biopharmaceutical production. The intellectual merit associated with this project is Alditri's ultimate development of a fundamental understanding of fibrous surface modification through vapor phase deposition techniques, thus enabling the technology for use in other applications. The surface