SBIR Phase I: Rapid Toxic Alcohols Detection Using On-Chip Biosensor Array for Emergency Care

Period of Performance: 01/01/2006 - 12/31/2006

$97.2K

Phase 1 SBIR

Recipient Firm

Siloam Biosciences
413 NORTHLAND BLVD
Cincinnati, OH 45219
Principal Investigator
Firm POC

Abstract

This Small Business Innovation Research (SBIR) Phase I Project is targeted towards the development of a biosensor array for point-of-care (POCT) detection of toxic alcohols. The sensor arrays would eventually be a part of a fully-disposable, plastic biochip which would be the first ever POCT system for diagnostics of toxic alcohol ingestion. This work will demonstrate the detection of methanol and Ethylene Glycol in the presence of Ethanol. Enzyme biosensors are used because of their specificity to a target - however, enzymes that catalyze alcohols show cross-reactivity to a range of alcohols which has precluded their use to-date. This research proposes a paradigm shift for enzymatic biosensors and to exploit this non-specific response and obtain clinically relevant information by using an array of microfabricated sensors and linear computations to calculate concentrations of toxic alcohols even in the presence of interferants.