SBIR Phase I: Nanobiotechnology for Identification of Membrane Proteins

Period of Performance: 01/01/2003 - 12/31/2003

$100K

Phase 1 SBIR

Recipient Firm

Novatarg Pharmaceuticals
22 Spruce Place
Demarest, NJ 07627
Principal Investigator

Abstract

This Small Business Innovation Research (SBIR) Phase I project will develop an innovative, rapid and low - cost nanotechnology that is ideally suited for industrial-scale identification of membrane protein structure. The main emphasis of this program is to develop a rapid and low-cost approach for fabrication of large membrane protein crystals, suitable for high-resolution structural analysis. The feasibility of the approach will be established using members from three different families of membrane proteins as prototypes for the crystallization process. Electron diffraction and microbeam x-ray crystallography using a synchrotron source will be employed for structure determination. In the follow on Phase II project, the technology will be further optimized to enhance resolution and increase throughput, suitable for industrial-scale applications.