Development of a Miniaturized Biological Detector

Period of Performance: 05/02/2000 - 11/02/2000

$70K

Phase 1 SBIR

Recipient Firm

Mesosystems Technology, Inc.
415 N. Quay, Bldg A, Suite 3
Kennewick, WA 99336
Principal Investigator

Abstract

The proposed approach is to miniaturize a biological detector by:·Capturing aerosols using a micromachined virtual impactor collector or MesoVICTM to deposit them on a tape surface for subsequent analysis. The amount of power consumed (100 liters of air/15 watts) with a collection efficiency found to be greater than 90% for particles larger than 1 micron is unparalleled performance. The minimization of consumable liquids in the collector is accomplished by dry sampling onto a tape.·This biosensor will utilize an ionized gas or plasma lysis stage to open cell and spore membranes. · The biological sensor approach is based on recent developments by JHU-APL to produce a miniature matrix-assisted laser desorption ionization (MALDI) mass spectrometer that rapidly (